Phenylpiperazine derivatives with a combination of partial...

Details Phenylpiperazine derivatives with a combination of partial... Phenylpiperazine derivatives with a combination of partial...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 263/58 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2587202

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1 ):wherein the symbols have the meanings given in the specification. and tautomers, stereoisomers and N - oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N -oxides.

L'invention concerne un groupe de nouveaux dérivés de phénylpipérazine avec un double mode d'action: inhibition de la réabsorption de sérotonine et agonisme partiel sur des récepteurs de dopamine-D2. L'invention concerne également l'utilisation d'un composé destiné à la fabrication d'un médicament. Les composés de cette invention sont représentés par la formule générale (1 ), dans laquelle les symboles sont tels que définis dans les spécifications. L'invention concerne également des tautomères, stréréoisomères et N-oxydes de ces composés, ainsi que des sels pharmaceutiquement acceptables, des hydrates et des solvates de ces composés de formule (1) ainsi que de leurs tautomères, stéréoisomères et N-oxydes.

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