Phenylpiperazine derivatives with a combination of partial...

Details Phenylpiperazine derivatives with a combination of partial... Phenylpiperazine derivatives with a combination of partial...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2587381

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

L'invention concerne un groupe de nouveaux dérivés de phénylpipérazine à double mode d'action: inhibition du recaptage de la sérotonine et agonisme partiel à l'égard des récepteurs D2 de la dopamine. L'invention concerne aussi l'utilisation d'un composé décrit en vue de la fabrication d'un médicament produisant un effet bénéfique. Les composés sont représentés par la formule générale (1), dans laquelle les symboles ont les notations données dans la spécification.

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