Phenylpiperazines with a combination of affinity for...

Details Phenylpiperazines with a combination of affinity for... Phenylpiperazines with a combination of affinity for...

C - Chemistry, Metallurgy

07

D

C07D 319/18 (2006.01) A61K 31/496 (2006.01) A61P 25/28 (2006.01) C07D 215/38 (2006.01) C07D 265/36 (2006.01) C07D 295/12 (2006.01) C07D 307/82 (2006.01) C07D 311/18 (2006.01) C07D 321/10 (2006.01)

Patent

CA 2587928

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine - D2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula ( 1 ) wherein the symbols have the meanings given in the specification.

L'invention concerne un groupe de nouveaux dérivés de phénylpipérazine ayant un double mode d'action: réabsorption de la sérotonine et inhibition de récepteurs de la dopamine D2, ainsi que des procédés permettant de préparer lesdits composés. L'invention concerne également l'utilisation d'un composé décrit ici même, utilisé pour produire un médicament à effet bénéfique. Lesdits composés sont de formule (I) dans laquelle les symboles ont les significations de la description.

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