(-)-phenylpropanolamine as a sympathomimetic drug

Details (-)-phenylpropanolamine as a sympathomimetic drug (-)-phenylpropanolamine as a sympathomimetic drug

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61P 11/02 (2006.01) A61P 11/08 (2006.01) A61P 27/08 (2006.01)

Patent

CA 2305294

The present invention provides pharmaceutical compositions which include (-)- phenylpropanolamine and a pharmaceutically acceptable carrier, wherein the (-)- phenylpropanolamine is substantially free of (+)-phenylpropanolamine. In another embodiment, the present invention provides methods of relieving nasal and bronchial congestion and of inducing pupil dilation which include administering a therapeutically effective amount of (-)-phenylpropanolamine to a mammal. The (-)-phenylpropanolamine used in the present methods is substantially free of (+)-phenylpropanolamine, and of the adverse side effects associated with administration of (+)-phenylpropanolamine.

La présente invention concerne des compositions pharmaceutiques qui comprennent de la (-)-phénylpropanolamine et un excipient acceptable sur le plan pharmaceutique, dans lesquelles la (-)-phénylpropanolamine ne contient pratiquement pas de (+)-phénylpropanolamine. Dans une autre réalisation, la présente invention concerne des procédés de suppression de congestions nasale et bronchique et inducteur de dilatation de pupille par administration, à un mammifère, d'une quantité thérapeutiquement efficace de (-)-phénylpropanolamine. La (-)-phénylpropanolamine utilisée dans ces procédés ne contient pratiquement pas de (+)-phénylpropanolamine et ne présente pas les effets secondaires néfastes associés au traitement avec la (+)-phénylpropanolamine.

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