Phenylpropenone compounds and medicines containing the same

Details Phenylpropenone compounds and medicines containing the same Phenylpropenone compounds and medicines containing the same

C - Chemistry, Metallurgy

07

C

C07C 49/255 (2006.01) C07C 45/74 (2006.01) C07C 235/34 (2006.01) C07C 235/38 (2006.01) C07D 213/74 (2006.01) C07D 239/42 (2006.01) C07D 295/02 (2006.01) C07D 295/04 (2006.01) C07D 295/185 (2006.01)

Patent

CA 2283257

Compound represented by general formula (1) or (2) and medicines containing the same, wherein R1, R2, and R3 represent each an alkyl or the like; R4 represents an alkyl, an alkoxy or the like; and -N(R5)R6 represents substituted phenylamino, substituted phenylpiperazinyl or the like. The compounds have potent ACAT inhibitory activities and can lower blood cholesterol level and inhibit the accumulation of cholesterol, thus being useful as prophylactic and therapeutic agents for human arteriosclerosis.

L'invention concerne un composé représenté par la formule générale (1) ou (2) ainsi que des médicaments le contenant, formules dans lesquelles R?1¿, R?2¿ et R?3¿ représentent chacun un alkyle ou analogue; R?4¿ représente un alkyle, un alcoxy ou analogue; et -N(R?5¿)R?6¿ représente phénylamino substitué, phénylpipérazinyle substitué ou analogue. Les composés présentent de puissantes activités inhibitrices de ACAT, ils peuvent abaisser le niveau de cholestérol dans le sang et inhiber l'accumulation de cholestérol, ce qui les rend utiles comme agents prophylactiques et thérapeutiques contre l'artériosclérose humaine.

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