Phenylpropionamide compounds and the use thereof

Details Phenylpropionamide compounds and the use thereof Phenylpropionamide compounds and the use thereof

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61K 31/454 (2006.01) A61K 45/06 (2006.01) A61P 25/04 (2006.01) A61P 29/02 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2666750

The invention relates to phenylpropionamide compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A, B, R1, R2, R3, R4 and R5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the activation of opioid receptors, particularly µ-opioid receptors. Compounds of the present invention are especially useful for treating pain.

L'invention concerne des composés de phénylpropionamide représentés par la formule (I) : et des sels pharmaceutiquement acceptables, des promédicaments et des solvates de ceux-ci, où A, B, R1, R2, R3, R4 et R5 sont tels que définis dans la description. L'invention concerne également l'utilisation des composés selon la formule (I) dans le but de traiter, prévenir ou améliorer un trouble susceptible de réagir à l'activation des récepteurs opioïdes, en particulier des récepteurs opioïdes µ. Les composés selon la présente invention sont particulièrement utiles pour le traitement de la douleur.

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