C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61K 31/4178 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01) A61P 19/06 (2006.01) A61P 19/08 (2006.01) A61P 25/02 (2006.01) A61P 25/08 (2006.01) A61P 25/16 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01) A61P 3
Patent
CA 2722102
A compound represented by the following general formula (1) or a salt thereof, which has superior inhibitory activity against type 4 PLA2, and thus has prostaglandin and/or leucotriene production suppressing action [X represents a halogen atom, an alkyl group which may be substituted, or the like, Y represents hydrogen atom or an alkyl group which may be substituted, and Z represents hydrogen atom or an alkyl group which may be substituted]. (see formula 1)
La présente invention concerne un composé représenté par la formule générale (1) (dans laquelle X représente un atome d'halogène, un groupe alkyle facultativement substitué ou similaire ; Y représente un atome d'hydrogène ou un groupe alkyle facultativement substitué ; et Z représente un atome d'hydrogène ou un groupe alkyle facultativement substitué) ou son sel. Le composé présente une excellente activité inhibitrice de la phospholipase A2 (PLA2) de type IV, et présente donc une activité inhibitrice des prostaglandines et/ou des leucotriènes.
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Asahi Kasei Pharma Corporation
Goudreau Gage Dubuc
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