Phenylpyridazine derivatives and drugs containing the same

Details Phenylpyridazine derivatives and drugs containing the same Phenylpyridazine derivatives and drugs containing the same

C - Chemistry, Metallurgy

07

D

C07D 237/08 (2006.01) A61K 31/50 (2006.01) A61P 9/10 (2006.01) A61P 19/10 (2006.01) A61P 29/00 (2006.01) C07D 237/10 (2006.01) C07D 237/12 (2006.01) C07D 237/14 (2006.01) C07D 237/18 (2006.01) C07D 237/20 (2006.01) C07D 237/24 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2413042

Compounds of the general formula (I) or salts thereof; and drugs containing the compounds or the salts: (I) [wherein R1 is optionally substituted phenyl, pyridyl, or the like; R2 is lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, or the like; R3 is hydrogen, lower alkoxy, or the like; and R4 is hydrogen, substituted alkyl, or the like]. The compounds exhibit an excellent interleukin 1.szlig. production inhibiting activity and are useful as preventive and therapeutic drugs for immunologic diseases, inflammatory diseases, ischemic disease, and so on.

L'invention concerne des composés de formule générale (I) ou des sels de ces derniers, ainsi que des médicaments contenant lesdits composés ou lesdits sels. Dans la formule (I), R?1¿ représente phényle, pyridyle ou similaire éventuellement substitué ; R?2¿ représente alkyle inférieur, alkylthio inférieur, alkylsulfinyle inférieur, alkylsulfonyle inférieur, ou similaire ; R?3¿ représente hydrogène, alcoxy inférieur ou similaire ; et R?4¿ représente hydrogène, alkyle substitué ou similaire. Ces composés présentent un excellent effet inhibiteur sur la production d'interleukine 1.beta., et servent de médicaments pour la prévention et la thérapie de maladies immunologiques, de maladies inflammatoires, de maladies ischémiques, etc.

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