C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/81 (2006.01) A61K 31/439 (2006.01) A61K 31/4418 (2006.01) A61K 31/4427 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5355 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/
Patent
CA 2448298
A compound represented by the following general formula, which has phosphodiesterase IV inhibitory activity; a use of the compound; and an intermediate therefor. (I) (In the formula, R1 and R2 each is hydrogen, halogeno, lower alkyl, lower alkoxy, etc.; R3 and R4 each is hydrogen, (substituted) lower alkyl, halogeno, etc.; R5 is hydrogen, lower alkyl, lower alkoxycarbonyl, etc.; and n is 0 or 1.)
La présente invention concerne un composé de formule générale (I), dans laquelle R1 et R2 représentent chacun hydrogène, halogéno, alkyle inférieur, alcoxy inférieur; R3 et R4 représentent chacun hydrogène, alkyle inférieur (substitué), halogéno; R5 représente hydrogène, alkyle inférieur, alcoxycarbonyl inférieur ; n est 0 ou 1. Ledit composé présente une activité d'inhibition de la phosphodiestérase IV. L'invention concerne également l'utilisation dudit composé, et un intermédiaire.
Iwata Masahiro
Kaizawa Hiroyuki
Kawano Noriyuki
Kobayashi Miki
Seo Ryushi
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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