C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/36 (2006.01) A61K 31/505 (2006.01) A61P 15/10 (2006.01)
Patent
CA 2746427
Phenyl pyrimidone compounds, pharmaceutical compositions, preparation methods and uses thereof. In particular to phenyl pyrimidone compounds of formula I, pharmaceutical acceptable salts or solvates, pharmaceutical compositions and preparation methods thereof. The compounds of formula I are effective for inhibiting V form phosphodiesterase enzyme (PDE5), and could be applied to treating various vein dysfunctional diseases such as male erectile dysfunction, pulmonary hypertension et al. (see formula I)
L'invention porte sur des composés de phénylpyrimidone, des compositions pharmaceutiques, leurs procédés de préparation et leurs utilisations. En particulier, l'invention porte sur des composés de phénylpyrimidone de formule I, leurs sels ou solvates pharmaceutiquement acceptables, des compositions pharmaceutiques et leurs procédés de préparation. Les composés de formule I sont efficaces pour l'inhibition de l'enzyme phosphodiestérase de type V (PDE5) et pourraient être appliqués au traitement de diverses maladies associées à une dysfonction veineuse telles qu'un dysfonctionnement érectile, l'hypertension pulmonaire et autres.
Jiang Hualiang
Jin Qing
Li Jianfeng
Liu Zheng
Shen Jingkang
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
Smart & Biggar
Topharman Shanghai Co. Ltd.
LandOfFree
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