C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/29 (2006.01) A61K 39/36 (2006.01) C07K 14/415 (2006.01) C12N 15/82 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2528053
The invention relates to the production and use of variants of the group 5 allergens of Pooideae, characterised in displaying a reduced IgE reactivity relative to known wild type allergens and also a substantially retained reactivity with T-lymphocytes. Said hypoallergenic allergen varieties can be used for specific immunotherapy (hyposensitisation) of patients with grass pollen allergies or for preventative immunotherapy of grass pollen allergies.
Production et utilisation de variants des allergènes du groupe 5 de Pooideae qui se caractérisent par une réactivité réduite à IgE par rapport aux allergènes de type sauvage connus et simultanément par une réactivité largement conservée vis-à-vis des lymphocytes T. Ces variants d'allergènes hypoallergéniques peuvent être utilisés pour une immunothérapie spécifique (hyposensibilisation) de patients souffrant d'allergies aux pollens de plantes herbacées ou pour l'immunothérapie préventive d'allergies aux pollens de plantes herbacées.
Cromwell Oliver
Fiebig Helmut
Kahlert Helga
Nandy Andreas
Wald Martin
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraekter Haftung
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