C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/57 (2006.01) A61P 9/04 (2006.01) C07K 14/47 (2006.01) C12N 9/16 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2638913
The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (1-1). In particular, the 1-1 mutant forms comprise altered phosphorylation sites of PKC-.alpha.. In addition, the present invention relates to methods of regulating cardiac contractility and function, and for treatment of cardio myopathy and heart failure, which employ the novel nucleic acids and polypeptides. Vectors comprising the novel nucleic acids, Antibodies to the novel proteins, and diagnostic and screening methods associated therewith, are also provided.
L'invention concerne de nouveaux acides nucléiques codant de nouvelles formes mutantes de la protéine-1 inhibiteur (1-1). En particulier, ces formes mutantes de 1-1 comprennent des sites modifiés de phosphorylation de PKC-.alpha.. L'invention concerne, de plus, des procédés de régulation de la contractilité et de la fonction cardiaque, ainsi que de traitement de la cardiomyopathie et de la défaillance cardiaque, qui mettent en application ces nouveaux acides nucléiques et ces nouveaux polypeptides. Elle concerne également des vecteurs comprenant ces nouveaux acides nucléiques, des anticorps contre ces nouvelles protéines et des méthodes associées de diagnostic et de criblage.
Kranias Evangelia
Mitton Bryan
Rodriguez Patricia
Gowling Lafleur Henderson Llp
The University Of Cincinnati
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