C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/34 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 413/00 (2006.01)
Patent
CA 2261793
The present invention is directed to compounds having formula (I), wherein R, R' and R''' are the same or different and are preferably hydrophobic groups, Z represents one or two bivalent segments and Y is H or is absent when Z represents two bivalent segments. R'' may be the same or different as R, R' and R''', and is absent when Z represents two bivalent segments. The invention further provides a method of making compounds according to formula (I). The compounds are useful as inhibitors of protein phosphatases, for example PP1, PP2A, PP3, CDC25A, CDC25B and CDC25C. The invention is further directed to a method of inhibiting a protein phosphatase, a method of inhibiting cell proliferation, and pharmaceutical compositions comprising the subject compounds.
L'invention concerne des composés représentés par la formule (I) dans laquelle R, R' et R''' sont semblables ou différents et représentent, de préférence, des groupes hydrophobes; Z représente un ou deux segments bivalents et Y représente H ou est absent quand Z représente deux segments bivalents. R'' peut être semblable à R, R' et R''' ou différent de ces derniers et est absent quand Z représente deux segments bivalents. L'invention concerne également un procédé de préparation de composés selon la formule I. Ces composés sont utiles en tant qu'inhibiteurs de protéines phosphatases, par exemple, PP1, PP2A, PP3, CDC25A, CDC25B et CDC25C. Elle concerne, de plus, un procédé servant à inhiber une protéine phosphatase, un procédé servant à inhiber la prolifération cellulaire, ainsi que des compositions pharmaceutiques contenant ces composés.
Cunningham April
Lazo John S.
Rice Robert L.
Wipf Peter
Smart & Biggar
University Of Pittsburgh
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