C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/14 (2006.01) A61K 31/10 (2006.01) A61K 31/18 (2006.01) A61K 31/404 (2006.01) A61K 31/405 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/416 (2006.01) A61K 31/4184 (2006.01) A61K 31/421 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61K 31/535 (2006.01) A61K 31/5375 (2006.01) A61P 3/10 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07C 311/09 (2006.01) C07C 317/22 (2006.01) C07C 317/32
Patent
CA 2382789
The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.
La présente invention concerne des composés trifluorométhyl sulfonyle et trifluorométhyl sulfonamido, leurs sels pharmaceutiquement acceptables et leurs promédicaments. Ces composés servent à moduler l'activité de protéine tyrosine enzymes impliquées dans la transduction du signal cellulaire, en particulier, de la protéine tyrosine phosphatase et peuvent pour cela être utilisés pour la prévention et le traitement des troubles liés à une transduction de signal cellulaire par protéine tyrosine enzyme anormale, telle que le cancer, les diabètes, l'immuno-modulation, les maladies neurologiques dégénérescentes, l'ostéoporose et les maladies infectieuses. Cette invention concerne également l'utilisation de composés contenant des groupes fluorométhyl sulfonyle comme mimétiques phosphates. Ces mimétiques peuvent être utilisés pour inhiber, réguler ou moduler l'activité d'une protéine à liaison phosphate dans une cellule.
Biltz John
Huang Ping
Jallal Bahija
Koenig Marcel
Li Sharon
Osler Hoskin & Harcourt Llp
Sugen Inc.
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