C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/09 (2006.01) C07C 305/12 (2006.01) C07C 305/18 (2006.01) C07C 307/02 (2006.01) C07F 9/38 (2006.01) C07F 9/572 (2006.01) C07F 9/58 (2006.01) C07F 9/59 (2006.01) C07F 9/6506 (2006.01) C07F 9/6509 (2006.01) C07F 9/6518 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2517281
Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.
Composés à base d'esters de sulfate/phosphate modulant et/ou inhibant l'activité de NIMA interagissant avec des protéines (PIN1) et compositions pharmaceutiques contenant de tels composés. L'invention se rapporte également à l'utilisation thérapeutique ou prophylactique de ces composés et compositions, et à des méthodes de traitement de troubles caractérisés par l'hypertension, la prolifération cellulaire indésirable, des maladies infectieuses et des troubles neurodégénératifs du cerveau, consistant à administrer des quantités efficaces de ces composés.
Dagostino Eleanor Ferronyalka
Dong Liming
Guo Chuangxing
Hou Xinjun
Margosiak Stephen Anthony
Pfizer Inc.
Sim & Mcburney
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