Phosphazene polyelectrolytes as immunoadjuvants

Details Phosphazene polyelectrolytes as immunoadjuvants Phosphazene polyelectrolytes as immunoadjuvants

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/16 (2006.01) C08G 79/02 (2006.01)

Patent

CA 2166208

An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is a poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.

L'invention concerne l'utilisation d'un polyélectrolyte soluble àbase de polyphosphazène. Dans une forme d'exécution, l'adjuvant polymère est un poly(organophosphazène) ayant (i) des groupes pendants ionisés ou ionisables contenant, par exemple, des groupes acide carboxylique, acide sulfonique ou hydroxyle et (ii) des groupes pendants pouvant s'hydrolyser lors de l'utilisation, pour rendre le polymère biodégradable.

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