C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/179, 260/291
C07K 5/06 (2006.01) A61K 31/675 (2006.01) C07F 9/547 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1326737
Abstract The invention provides compounds of the formula Image I wherein R1-R5 and X have the significance given in the description, and their pharmaceutically acceptable salts. They inhibit the enzyme collagenase and can be used in the form of medicaments for the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis. The compounds of formula I and their pharmaceutically acceptable salts can be manufactured according to generally known methods.
553634
Broadhurst Michael John
Handa Balraj Krishan
Johnson William Henry
Lawton Geoffrey
Machin Peter James
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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