Phosphinic acid derivatives and process for preparing the same

Details Phosphinic acid derivatives and process for preparing the same Phosphinic acid derivatives and process for preparing the same

C - Chemistry, Metallurgy

07

F

260/458.8

C07F 9/30 (2006.01) C07F 9/32 (2006.01)

Patent

CA 1212120

ABSTRACT OF THE DISCLOSURE: A novel intermediate product for use in producing [(3-amino-carboxy)-propyl-1)] phosphinic acid derivatives. This product is represented by the formula (V'): Image (V') wherein R1 and R2 are same or different and each represent a straight or branched chain alkyl group having from 1 to 5 carbon atoms, an aryl group selected from the group con- sisting of phenyl, chlorophenyl, nitrophenyl and methoxy- phenyl, or an benzyl group, R3 and R4 are same or diffe- rent and R3, R4 and R5 each represent a hydrogen atom, a straight or branched chain alkyl group having from 1 to 5 carbon atoms, an aryl group selected from the group con- sisting of phenyl, chlorophenyl, nitrophenyl and methoxy- phenyl, or a benzyl group, provided that R3 and R4 are not hydrogen atoms at the same time. The product (V') may be transformed, without isolation, into the corresponding [(3-amino-3-carboxy)-piopyl-1] phosphinic acid derivative by means of a conventional deprotecting method such as hydrolysis.

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