C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/30 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01) C07F 9/58 (2006.01) C07F 9/6512 (2006.01) C07F 9/6539 (2006.01) C07F 9/655 (2006.01) C07F 9/6553 (2006.01)
Patent
CA 2224555
Compounds of formula (I) wherein R, R1, R2, R3, R4 and <u>n</u> have the meanings reported in the description are described. The compounds of formula (I) are endowed with a dual ACE-inhibitory and NEP-inhibitory activity and are useful in the treatment of cardiovascular diseases.
La présente invention se rapporte à des composés de formule (I), dans laquelle, R, R¿1?, R¿2?, R¿3?, R¿4? et <u>n</u> sont tels que définis dans la description. Les composés de formule (I) possèdent une double activité inhibitrice par rapport à l'ACE (enzyme convertissant l'angiotensine) et à la NEP (endopeptidase neutre) et conviennent au traitement des maladies cardio-vasculaires.
Botta Daniela
Norcini Gabriele
Santangelo Francesco
Semeraro Claudio
Riches Mckenzie & Herbert Llp
Zambon Group Spa
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