Phosphoantigen salts of organic bases and methods for their...

A - Human Necessities – 61 – K

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A61K 31/663 (2006.01) C07F 9/09 (2006.01) C07F 9/38 (2006.01)

Patent

CA 2624533

The invention provides novel phosphoantigen salts and novel crystalline phases of phosphoantigens salts, that the latter including non-solvated polymorphs, and solvates useful as pharmaceuticals. The invention also provides pharmaceutical compositions comprising, and processes for making, novel phosphoantigen crystalline phases. Methods of using such compositions for the treatment of disease, immunostimulatory or immune response modifiying use are also provided. The invention also provides method for obtaining phosphoantigen crystals as well as highly pure phosphoantigen compositions.

Sels phosphoantigènes et phases cristallines de ces sels, renfermant des polymorphes non solvatés, et solvates utiles comme substances pharmaceutiques. Egalement, compositions pharmaceutiques renfermant les phases cristallines phosphoantigènes considérées, et procédés d'élaboration correspondants. Procédés d'utilisation relatifs à ces compositions pour le traitement de maladies et pour la modification de réponse immunostimulatrice ou immune. Enfin, procédé d'élaboration de cristaux phosphoantigènes et de compositions phosphoantigènes de grande pureté.

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