C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/17 (2006.01) C07K 16/40 (2006.01) C07K 16/42 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/12 (2006.01) C12N 9/16 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2321224
The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
La présente invention concerne de nouveaux polypeptides humains PDE10, des polynucléotides codant pour ces polypeptides, des constructions d'expression renfermant ces polynucléotides, des cellules hôtes transformées au moyen des constructions d'expression; des techniques de fabrication de polypeptides PDE10, des polynucléotides antisens; et des anticorps spécifiquement immuno-réactifs avec les polypeptides PDE10. Cette invention concerne par ailleurs des techniques permettant d'identifier des partenaires de liaison des PDE10 et, plus particulièrement, de ceux d'entre eux qui modulent l'activité enzymatique de PDE10.
Icos Corporation
Ridout & Maybee Llp
LandOfFree
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