Phosphodiesterase 10 inhibition as treatment for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/535 (2006.01) A61K 31/137 (2006.01) A61K 31/365 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/48 (2006.01) A61K 31/517 (2006.01) A61K 38/00 (2006.01) A61K 38/22 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2568929

The present invention provides methods to decrease body weight and/or body fat in animals, e.g., in the treatment of overweight or obese patients (e.g., humans or companion animals), or as a means to produce leaner meat in food stock animals (e.g., cattle, chickens, pigs), methods to treat non-insulin dependent diabetes (NIDDM), metabolic syndrome, or glucose intolerance, in patients in need thereof by administering a PDE10 inhibitor (alone or in combination with another therapeutic agent), kits for the above-identified therapeutic uses, and methods of identifying PDE10 inhibitors for the above- described therapeutic uses.

L'invention concerne des méthodes de réduction du poids corporel et/ou de la graisse corporelle chez les animaux, par exemple dans le traitement de patients souffrant de surpoids ou d'obésité (par exemple les humains ou les animaux de compagnie), ou de production de viande plus maigre chez les animaux utilisés dans l'alimentation (par exemple, le bétail, la volaille, les porcins). L'invention concerne également des méthodes de traitement du diabète non insulino-dépendant (NIDDM), du syndrome métabolique et de l'intolérance au glucose chez les patients en souffrant, par administration d'un inhibiteur de PDE10 (seul ou combiné à un autre agent thérapeutique), des kits utilisés dans lesdits traitements thérapeutiques, et des méthodes d'identification des inhibiteurs de PDE10 pour lesdits traitements thérapeutiques.

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