C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/517 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2619462
Provided are certain quinazolines of formular (I) or (II) that are PDElO inhibitors, pharmaceutical compositions, containing the same and processes for preparing the same. Also provided are methods of treating diseases treatable by PDElO enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like, by administering those certain quinasolines .
La présente invention se rapporte à certaines quinasolines de la formule (I) ou (II) qui sont des inhibiteurs de PDElO, à des compositions pharmaceutiques, contenant les mêmes procédés pour la préparation de ces quinasolines. Cette invention concerne également des procédés de traitement de maladies traitables par l~enzyme PDElO comme l~obésité, les diabètes non insulinodépendants, la schizophrénie ou le trouble bipolaire, les troubles obsessionnels compulsifs, et les pathologies cliniques semblables, en administrant certaines quinasolines .
Arrington Mark Philip
Conticello Richard D.
Gauss Carla Maria
Hitchcock Stephen
Hopper Allen
Amgen Inc.
Memory Pharmaceuticals Corporation
Osler Hoskin & Harcourt Llp
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