Phosphodiesterase 2a and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/55 (2006.01) A01K 67/027 (2006.01) C07K 16/40 (2006.01) C12N 5/06 (2006.01) C12N 9/16 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2520866

The invention relates to phosphodiesterase PDE2A isoforms, as well as nucleic acids encoding such polypeptides. The invention further relates to methods for utilizing such polypeptides in diagnostic assays and in methods of screenin potential modulators, especially inhibitors, of the novel PDE2A disclosed herein. The polypeptides of the invention are involved in many physiological processes including, e.g. the formation of memory, cognitive function, and other disease and conditions which involve or are mediated by PDE2A and its signaling pathways.

L'invention porte sur des isoformes de phosphodiestérase PDE2A ainsi que sur des acides nucléiques codant ces polypeptides. L'invention porte également sur des procédés d'utilisation de ces polypeptides dans des essais diagnostiques et dans des procédés de criblage de modulateurs potentiels, notamment des inhibiteurs, de la nouvelle PDE2A. Les polypeptides de l'invention sont impliqués dans de nombreux processus physiologiques tels que la formation de la mémoire, de la fonction cognitive, et dans d'autres maladies et états qui comprennent ou sont induits par PDE2A et ses mécanismes d'action signalétiques.

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