C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/06 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2278217
The present invention presents compounds that inhibit phosphodiesterase 4 having Formula (I). The present invention also provides methods of using the compounds of Formula (I) to prevent or treat asthma, atopic dermatitis, rheumatoid arthritis, inflammatory bowel disorders, pulmonary hypertension, liver injury, bone loss, septic shock, or multiple sclerosis, and to pharmaceutical compositions that contain the compounds of Formula (I).
La présente invention concerne des composés inhibant la phosphodiestérase 4 et correspondant à la formule (I). Elle concerne également des procédés d'utilisation des composés de la formule (I), dans la prévention ou le traitement de l'asthme, des dermatites atopiques, de la polyarthrite rhumatoïde, des colopathies fonctionnelles, de l'hypertension artérielle pulmonaire, des atteintes hépatiques, de la raréfaction osseuse, des chocs septiques ou de la sclérose en plaques. L'invention concerne encore des compositions pharmaceutiques contenant les composés de la formule (I).
Burnouf Catherine
Calvet Alain
Dahl Svein Gunwald
Gaudilliere Bernard
Jacobelli Henry
Macrae & Co.
Parke-Davis
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