Phosphodiesterase inhibitor

Details Phosphodiesterase inhibitor Phosphodiesterase inhibitor

A - Human Necessities

61

K

A61K 31/47 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61K 45/00 (2006.01) A61P 1/00 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 215/18 (2006.01) C07D 215/

Patent

CA 2493854

A phosphodiesterase 10A inhibitor which contains as an active ingredient a quinoline derivative represented by the following formula (I) or a pharmacologically acceptable salt of the derivative. (I) [In the formula, n is an integer of 1 to 4; R1 represents (un)substituted lower alkyl, -C(=Y)R9, etc.; R2 represents hydrogen, (un)substituted lower alkyl, etc.; R3 represents (un)substituted lower alkyl, (un)substituted aryl, (un)substituted heterocyclic group, etc.; and R4 represents halogeno, etc.]

L'invention concerne un inhibiteur de phosphodiestérase (10A) qui contient en tant que principe actif un dérivé de quinoline représenté par la formule (I), ou un sel de ce dérivé acceptable sur le plan pharmacologique. Dans la formule (I), n prend la valeur d'un entier compris entre 1 et 4; R?1¿ représente un alkyle inférieur (non) substitué, -C(=Y)R?9¿, etc.; R?2¿ représente un hydrogène, un alkyle inférieur (non) substitué, etc.; R?3¿ représente un alkyle inférieur (non) substitué, un aryle (non) substitué, un groupe hétérocyclique (non) substitué, etc.; et R?4¿ représente un halogéno, etc..

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