Phosphoglycan messengers and their medical uses

Details Phosphoglycan messengers and their medical uses Phosphoglycan messengers and their medical uses

C - Chemistry, Metallurgy

07

G

C07G 3/00 (2006.01) A61K 31/70 (2006.01) A61P 3/00 (2006.01) C07H 1/08 (2006.01) C07H 11/04 (2006.01)

Patent

CA 2427811

Phosphoglycan messengers (PGMs) which are carbohydrate derivatised phosphatidyl cyclitols are disclosed, together with the finding that these substances are biologically active, especially in modulating plasma cholesterol, plasma triglycerides and/or high density lipoprotein levels and/or modulating the LDL:HDL ratio, and for the treatment of lipodystrophy or dyslipidemia. These compounds are distinct from GPI-anchors disclosed in the prior art as these GPI-anchors are protein linked and are not biologically active.

L'invention concerne des messagers phosphoglycane (PGM) qui sont des phosphatidyl cyclitols dérivés de glucides, ainsi que la découverte selon laquelle ces matières sont biologiquement actives, notamment dans la modulation du cholestérol plasmatique, de triglycérides plasmatiques et/ou de taux de lipoprotéines de haute densité, et/ou dans la modulation du rapport LDL/HDL, et pour traiter la lipodystrophie ou la dyslipidémie. Ces composés se distinguent d'ancres GPI divulguées précédemment en ce que lesdites ancres GPI se lient aux protéines et ne sont pas biologiquement actives.

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