A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2730540
The invention relates generally to methods for inhibiting angiogenesis. More particularly, methods for inhibiting angiogenesis comprise selectively inhibiting phosphoinositide 3-kinase delta (P13K.delta.) activity in endothelial cells. The methods may comprise administration of one or more cytotoxic therapies including but not limited to radiation, chemotherapeutic agents, photodynamic therapies, radiofrequency ablation, anti-angiogenic agents, and combinations thereof.
Hallahan Dennis
Hayflick Joel S.
Sadhu Chanchal
Icos Corporation
Ridout & Maybee Llp
Vanderbilt University
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