Phosphoinositide 3-kinase delta selective inhibitors for...

Details Phosphoinositide 3-kinase delta selective inhibitors for... Phosphoinositide 3-kinase delta selective inhibitors for...

A - Human Necessities

61

K

A61K 31/52 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2566436

The invention relates generally to methods for inhibiting angiogenesis. More particularly, methods for inhibiting angiogenesis comprise selectively inhibiting phosphoinositide 3-kinase delta (P13K.delta.) activity in endothelial cells. The methods may comprise administration of one or more cytotoxic therapies including but not limited to radiation, chemotherapeutic agents, photodynamic therapies, radiofrequency ablation, anti-angiogenic agents, and combinations thereof.

L'invention concerne généralement des procédés pour inhiber l'angiogenèse. Plus particulièrement, des procédés pour inhiber l'angiogenèse comprennent sélectivement l'inhibition de l'activité de la phosphoinositide-3-kinase delta (P13K.delta.) dans les cellules endothéliales. Les procédés peuvent comprendre l'administration d'une ou plusieurs thérapies cytotoxiques, y compris entre autres l~irradiation, les agents chimiothérapiques, les thérapies photodynamiques, l~ablation par radiofréquence, les agents anti-angiogéniques, et les combinaisons de ceux-ci.

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