C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2650295
Compounds of Formulas (Ia) and (Ib), and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula (Ia) and (Ib) for in vitro, in situ, and in vivodiagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
L'invention concerne des composés de Formules (Ia et Ib) ainsi que des stéréoisomères, des isomères géométriques, des tautomères, des solvates, des métabolites et leurs sels pharmaceutiquement acceptables utiles pour inhiber les kinases lipides contenant P13K et pour traiter les troubles tels que le cancer véhiculé par les kinases lipides. L'invention porte également sur des procédés d'utilisation de composés de Formules (Ia et Ib) destinés au diagnostic, à la prévention ou au traitement in vitro, in situ et in vivo desdits troubles dans des cellules mammifères ou d'états pathologiques associés.
Bayliss Tracy
Castanedo Georgette
Dotson Jennafer
Folkes Adrian
Goldsmith Richard
F. Hoffmann-La Roche Ag
Genentech Inc.
Smart & Biggar
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