Phosphoinositide 3-kinase inhibitors for inhibiting...

Details Phosphoinositide 3-kinase inhibitors for inhibiting... Phosphoinositide 3-kinase inhibitors for inhibiting...

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 31/517 (2006.01) A61K 31/52 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2598409

The invention relates generally to phosphoinositide 3-kinases (PI3Ks) , and more particularly to methods of inhibiting leukocyte accumulation comprising selectively inhibiting phosphoinositide 3-kinase delta (PI3K.delta.) and phosphoinositide 3-kinase gamma (PI3K.gamma.) activities in endothelial cells. The disclosed methods may be used to treat individuals having an inflammatory condition where leukocytes are found to be accumulating at the site of insult or inflamed tissue. The inflammatory condition may be attributed to or associated with an underlying disorder not typically associated with inflammation, e.g. cancer, coronary vascular disease, etc.

D'une manière générale, la présente invention a trait à des phosphoinositide 3-kinases (PI3Ks), et plus particulièrement à des procédés d'inhibition d'accumulation de leucocytes comprenant l'inhibition sélective des activités de 3-kinase delta (PI3Kd) et phosphoinositide 3-kinase gamma (PI3K?) dans des cellule endothéliales.

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