Phosphoinositide 3-kinase inhibitors with a zinc binding moiety

Details Phosphoinositide 3-kinase inhibitors with a zinc binding moiety Phosphoinositide 3-kinase inhibitors with a zinc binding moiety

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2749228

The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase.

La présente invention concerne les déazapurines, les thiénopyrimidines et les furopyrimidines avec des dérivés à base de fraction de liaison au zinc et leur utilisation dans le traitement de maladies et de troubles, tels que le cancer, associés à la phosphoinositide 3-kinase. La présente invention concerne en outre le traitement de troubles associés à l'histone déacétylase et de maladies associées à la fois à l'histone déacétylase et à la phosphinositide 3-kinase.

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