A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/683 (2006.01)
Patent
CA 2607183
The present invention relates to methods of treating Alzheimer's Disease which utilize agents that increase neuronal phosphotidylinositol 4,5- biphosphate (PIP2), and to differentiated stem cell-based assay systems that may be used to identify agents that modulate phosphoinositide levels and thereby treat a variety of diseases. It is based, at least in part, on the discovery that edelfosine, an agent that increases PIP2 levels by inhibiting an enzyme that catalyzes PIP2 breakdown, decreases levels of neurotoxic A.beta.42 peptide, particularly in cells expressing a mutant presenilin gene associated with Familial Alzheimer' s Disease.
L'invention concerne des méthodes permettant de traiter la maladie d'Alzheimer à l'aide d'agents qui augmentent le phosphotidylinositol 4,5- biphosphate (PIP2) neuronal et de systèmes de dosage à base de cellules souches différenciées pouvant être utilisées pour identifier des agents qui modulent les niveaux de phosphoinositide et permettent donc de traiter une variété de maladies. Ces méthodes sont fondées, au moins partiellement, sur la découverte que l'édelfosine est un agent qui permet d'augmenter les niveaux de PIP2 par inhibition d'une enzyme qui catalyse la décomposition de PIP2 et réduit les niveaux de peptide Aß42 neurotoxique, en particulier, dans des cellules exprimant un gène mutant de préséniline associé à la maladie d'Alzheimer familiale.
Kim Tae-Wan
Landman Natalie
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Trustees Of Columiba University In The City Of New York
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