Phospholipase a_ inhibiting compositions and their use

Details Phospholipase a_ inhibiting compositions and their use Phospholipase a_ inhibiting compositions and their use

A - Human Necessities

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A61K 47/48 (2006.01) A61K 31/685 (2006.01) C08B 11/12 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1327936

"PHOSPHOLIPASE A2 INHIBITING COMPOSITIONS AND THEIR USE" ABSTRACT OF THE DISCLOSURE Inhibitors of phospholipase A2 activity at the cell-surface membrane whose molecular structure comprises a cell-permeable PLA2-inhibitor moiety covalently bonded directly or indirectly to a physiologically acceptable carrier moiety which is effective to inhibit cell internalization of the cell- permeable PLA2-inhibitor moiety, with the proviso that phosphatidylserine is not bonded indirectly via divalent dodecanedioyl to dextrane hydrazide.

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