Phospholipase inhibitors localized in the gastrointestinal...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/66 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2565384

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

L'invention concerne des méthodes et des compositions destinées au traitement d'états associés à la phospholipase. L'invention concerne en particulier une méthode de traitement d'états associés à l'insuline, au poids et/ou des états associés au cholestérol chez un sujet animal. La méthode de l'invention consiste généralement à administrer un inhibiteur de phospholipase A2 non absorbé et/ou résultant d'un écoulement qui est localisé dans une lumière gastro-intestinale.

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