Phospholipid compositions and uses thereof

Details Phospholipid compositions and uses thereof Phospholipid compositions and uses thereof

A - Human Necessities

61

K

A61K 31/661 (2006.01) A61K 31/14 (2006.01) A61K 31/685 (2006.01) A61K 31/739 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2705530

We have discovered that phospholipids diundecanoyl (Cl 1:0-C1 1:0) and dilauroyl (C12:0-C12:0) phosphatidyl- choline (PC) act as agonists of the LRH-1 receptor. We have also shown that administration of these lipids to diabetic mice reduces blood glucose levels. On the basis of these discoveries, the present invention features compositions that include these lipids and structurally related lipids. Also featured are methods of treating metabolic disorders and inflammatory bowel disease, lowering blood glucose levels, and increasing LRH-1 receptor activity in a subject by administration of these lipids.

Nous avons découvert que les phospholipides diundécanoyl (C1 1:0-C1 1:0) et dilauroyl (C12:0-C12:0) phosphatidylcholine (PC) agissent tels des agonistes du récepteur LRH-1. Nous avons également montré que l'administration de ces lipides à des souris diabétiques réduit les taux de glucose dans le sang. Sur la base de ces découvertes, la présente invention porte sur des compositions qui comprennent ces lipides et des lipides de structure associée. L'invention porte également sur des procédés de traitement de troubles métaboliques et de l'infection abdominale inflammatoire, de diminution des taux de glucose dans le sang et d'augmentation de l'activité du récepteur LRH-1 chez un sujet par l'administration de ces lipides.

Affiliated with

Also associated with

Rating

Phospholipid compositions and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phospholipid compositions and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phospholipid compositions and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1448173