Phospholipid derivatives

Details Phospholipid derivatives Phospholipid derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/576 (2006.01) A61K 31/675 (2006.01) C07F 9/547 (2006.01) C07F 9/553 (2006.01) C07F 9/572 (2006.01) C07F 9/59 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2100228

Compounds of the general formula I (see formula I) in which: R is a straight-chain or branched alkyl radical having 10 to 24 carbon atoms, which also can contain one to three double or triple bonds; R1 and R2, independently of one another, are hydrogen, or each is a straight-chain or branched saturated alkyl radical having 1 to 6 carbon atoms, a straight-chain or branched unsaturated alkyl radical having 2 to 6 carbon atoms, or a cyclic saturated or unsaturated alkyl radical having 3 to 6 carbon atoms, which also can contain a Cl, OH or NH2 group; and where straight-chain or branched alkyl radicals R1 and R2 also can be bonded together to form a ring; A is a single bond or one of the groups having the formulae -CH2-CH2-CH2-O- (II) -CH2-CH2-O- (III) (see formula IV) -s-(CH2)8-O- (V) (see formula VI) wherein: the groups (II) to (VI) are arranged such that the oxygen atom is bonded to the phosphorus atom of the compound (I); X is an oxygen or sulphur atom, or NH if A is a single bond, or is an oxygen or sulphur atom if A is one of the groups (II) to (VI); y is 0 or a natural number between 1 and 3; and m + n independently of one another are 0 or natural numbers, with the proviso that m + n = 2 to 8; and pharmaceutically-acceptable salts thereof. These novel phospholipid derivatives are useful for treating tumours, protozoal and fungal diseases, autoimmune diseases, skin diseases, bone marrow damage due to treatment with cytostatic and other myelotoxic agents, and viral diseases. Preparation and purification methods for the compound are also disclosed.

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