Phospholipid derivatives containing phosphorous, arsenic,...

Details Phospholipid derivatives containing phosphorous, arsenic,... Phospholipid derivatives containing phosphorous, arsenic,...

C - Chemistry, Metallurgy

07

F

C07F 9/94 (2006.01) A61K 31/66 (2006.01) A61P 35/00 (2006.01) C07F 9/02 (2006.01) C07F 9/54 (2006.01) C07F 9/66 (2006.01) C07F 9/72 (2006.01) C07F 9/90 (2006.01)

Patent

CA 2107439

Phospholipid derivatives containing higher elements of the Vth main group (P, As, Sb, Bi), their method of preparation and antineoplastic and antimicrobially active medicaments that can be prepared from the phospholipid derivatives are described. The derivatives have the general formulas: Image wherein R5 is a C10-24 alkyl radical with up to three double and/or triple bonds; A is a single bond or various organic radicals; X is -O-, -S-, or -NH- when A is H or X is -O- or -S- when A is an organic radical: A1 is a saturated or unsaturated C2-10 alkyl radical which may be substituted by a halogen or -OH; and R6 is (+)YR8R9R10, wherein R8-R10 are straight, branched or cyclic C1-6 alkyl radicals or H, and Y is P, As, Sb or Bi or one of P, As or Sb bound in a cyclic radical.

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