Phospholipid derivatives of non-steroidal anti-inflammatory...

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 9/02 (2006.01) A61K 31/66 (2006.01) C07F 9/10 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2346869

The invention discloses compounds comprising non-steroidal anti-inflammatory drugs (NSIDs) covalently linked to a phospholipid moiety via a bridging group. The invention further discloses a process for the synthesis of said compounds, pharmaceutical compositions comprising them and the use thereof for the treatment of diseases and disorders related to inflammatory conditions, as shown in the Figure, the treatment of ischemia.

La présente invention concerne des composés renfermant des médicaments anti-inflammatoires non stéroïdiens (AINS) liés par covalence à une fraction phospholipidique via un groupe de pontage. Par ailleurs, cette invention concerne un processus de synthèse de ces composés, des compositions pharmaceutiques les renfermant, ainsi que leur utilisation dans le traitement des maladies et des troubles liés à des états inflammatoires, representé par la figure, et dans le traitement de l'ischémie.

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