Phospholipid derivatives, their production and use

Details Phospholipid derivatives, their production and use Phospholipid derivatives, their production and use

C - Chemistry, Metallurgy

07

F

167/179, 260/290

C07F 9/10 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01) C07F 9/58 (2006.01)

Patent

CA 1297102

Abstract of the Disclosure Phospholipid derivatives of the formula: Image wherein Rl is a higher alkyl, acylmethyl or alkylcarbamoyl group which may be substituted by cycloalkyl; R2 is a lower alkyl which may be substituted by carboxy, formyl or lower acyl, a carbamoyl or thiocarbamoyl group which is substituted by lower alkyl, or an acetoacetyl group; R3, R4 and R5 are independently hydrogen ox lower alkyl, or Image represents a cyclic ammonio group; and n represents an integer of 8 to 14, and salts thereof have antitumor activity and platelet activating factor inhibitory activity and are useful as antitumor agents.

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