Phospholipid formulations and uses thereof in lung disease...

Details Phospholipid formulations and uses thereof in lung disease... Phospholipid formulations and uses thereof in lung disease...

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 31/66 (2006.01) A61K 31/685 (2006.01)

Patent

CA 2606688

Disclosed are methods and compositions that are useful in the detection and therapy of diseases (e.g., emphysema) and damage that afflict the lungs. In some aspects, the compositions comprise a formulation enriched for a species of phosphatidylcholine, such as palmitoylmyristoyl phosphatidylcholine (16:0/14:0PC). The compositions may further be described as lung surfactant supplement preparations particularly useful in the treatment of pulmonary diseases and afflictions prevalent among premature infants, and in particular, Respiratory Distress Syndrome (RDS). A PC marker is also disclosed, 16:0/14:0PC, that may be used to detect pulmonary disease or reduced/compromised alveolar function in an animal. Phospholipid profiles of 16:0/14:0PC, 16:0/16:1PC and 16:0/16:0PC are also provided, and are correlated with particular pulmonary diseased states.

L'invention concerne des méthodes et des compositions s'utilisant dans la détection et le traitement de pathologies (par ex. l'emphysème) et les troubles affectant les poumons. Dans certains aspects, les composants comprennent une formulation enrichie pour une espèce de phosphatidylcholine, telle que la palmitoylmyristoyle phosphatidylcholine (16:0/14:OPC). Lesdites compositions peuvent en outre être décrites comme des préparations supplétives par apport de tensioactif à usage pulmonaire, particulièrement efficaces dans le traitement de maladies pulmonaires et d'affections prévalant chez les prématurés et plus particulièrement, le syndrome de détresse respiratoire (SDR). L'invention concerne également un marqueur de PC, 16:0714:OPC, pouvant s'utiliser pour détecter des maladies pulmonaires ou une fonction alvéolaire réduite/affaiblie chez l'animal. L'invention concerne également des profils de phospholiques de 16:0/14:OPC, 16:0/16:1PC et 16:0/16:OPC et sont corrélés avec des états pathologiques pulmonaires particuliers.

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