Phospholipid- or lipid-linked glycosaminoglycan, process for...

Details Phospholipid- or lipid-linked glycosaminoglycan, process for... Phospholipid- or lipid-linked glycosaminoglycan, process for...

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01) A61K 31/725 (1990.01)

Patent

CA 2067211

This invention relates to compounds prepared by linking glycosaminoglycan to phospholipid or lipid, which are expected to exert a pharmacological effect for inhibiting metastasis because of their excellent function to inhibit adhesion of cancer cells to blood vessel endothelial cells and extracellular matrix. This phospholipid- or lipid-linked glycosaminoglycan can be produced for example by: cleaving and oxidizing reducing terminal group of glycosaminoglycan, and allow- ing an aldehyde group or a lactone compound of the thus- formed derivative or a carboxyl group in the glycos- aminoglycan chain to react with a primary amino group of a phospholipid; or linking a glycosaminoglycan deriva- tive to a phospholipid or a lipid by allowing a primary amino group of the derivative to react with a carboxyl group of the phospholipid or lipid. This phospholipid- or lipid-linked glycosaminoglycan is useful as a metastasis inhibitor because it has no toxicity.

Affiliated with

Also associated with

Rating

Phospholipid- or lipid-linked glycosaminoglycan, process for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phospholipid- or lipid-linked glycosaminoglycan, process for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phospholipid- or lipid-linked glycosaminoglycan, process for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1394013