Phosphonate compounds

Details Phosphonate compounds Phosphonate compounds

A - Human Necessities

61

K

A61K 31/675 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2747954

The present invention relates to phosphonate compounds having the formula: (see above formula) wherein R1, R1', R2, R2', X, and m are as defined in the specification; R3 is a pharmaceutically active phosphonate, bisphosphonate or a phosphonate derivative of a pharmacologically active compounds, linked to a functional group on optional linker L or to an available oxygen atom on C a; L is a valence bond or a bifunctional linking molecule of the formula -J- (CR2)t-G-, wherein t is an integer from 1 to 24, each of J and G is independently -O-, -S- , -C(O)O-, or --NH-, and R is -H, substituted or unsubstituted alkyl, or alkenyl; and n is 0 or 1. Also provided are compositions containing these phosphonate compounds, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections.

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