C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/28 (2006.01) A61K 31/675 (2006.01) A61P 31/12 (2006.01) C07F 9/40 (2006.01) C07F 9/6512 (2006.01) C07F 9/6561 (2006.01) C07F 9/6571 (2006.01) C07H 19/10 (2006.01)
Patent
CA 2393410
The present invention relates to phosphonate compounds having the formula: (see above formula) wherein R1, R1', R2, R2', X, and m are as defined in the specification; R3 is a pharmaceutically active phosphonate, bisphosphonate or a phosphonate derivative of a pharmacologically active compounds, linked to a functional group on optional linker L or to an available oxygen atom on C a; L is a valence bond or a bifunctional linking molecule of the formula -J- (CR2)t-G-, wherein t is an integer from 1 to 24, each of J and G is independently -O-, -S- , -C(O)O-, or - NH-, and R is -H, substituted or unsubstituted alkyl, or alkenyl; and n is 0 or 1. Also provided are compositions containing these phosphonate compounds, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections.
La présente invention concerne des composés de phosphonate, des compositions contenant ceux-ci, des procédés permettant de les obtenir, et leur utilisation dans le traitement d'une variété de troubles médicaux comme, par exemple, l'ostéoporose et d'autres troubles du métabolisme osseux, le cancer, les infections virales, et analogues.
Beadle James R.
Hostetler Karl Y.
Kini Ganesh D.
Mbm Intellectual Property Law Llp
Regents Of The University Of California
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