Phosphonate nucleotide compound

Details Phosphonate nucleotide compound Phosphonate nucleotide compound

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2263286

Phosphonate nucleotide compounds represented by general formula (I), their salts, hydrates and solvates thereof, and drugs containing the same, wherein R1 represents C1-6 alkyl, etc.; R2 represents hydrogen, halogenated C1-4 alkyl, etc.; R3 represents hydrogen, halogenated C1-4 alkyl, etc.; R4 represents hydrogen, halogenated C1-4 alkyl, etc.; and X represents carbon or nitrogen. These drugs are useful as antiviral agents for human immunodeficiency virus, herpes simplex virus, hepatitis B virus, etc., and as antitumor agents.

L'invention porte sur des composés nucléotidiques à base de phosphonate représentés par la formule générale (I), sur leurs sels, sur les hydrates et solvates de ceux-ci et sur les médicaments les contenant. Dans cette formule, R?1¿ représente un alkyle en C¿1-6?, etc.; R?2¿ représente l'hydrogène, un alkyle en C¿1-4? halogéné, etc.; R?3¿ représente l'hydrogène, un alkyle en C¿1-4? halogéné, etc.; R?4¿ représente l'hydrogène, un alkyle en C¿1-4? halogéné, etc.; et X représente un carbone ou un azote. Ces médicaments sont utilisés comme agents antiviraux dans le virus de l'immunodéficience humaine, le virus de l'herpès, le virus de l'hépatite B, etc., et comme agents antitumoraux.

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