Phosphonate nucleotide derivatives

Details Phosphonate nucleotide derivatives Phosphonate nucleotide derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01)

Patent

CA 2224710

A compound represented by general formula (I) and having an antiviral activity, wherein R1 represents hydrogen, C1-6 alkyl or C7-10 aralkyl; R2 represents C1-6 alkyl, C7-10 aralkyl or phenyl; R3 and R4 independently represent each hydrogen, C1-6 alkyl, acyloxymethyl, acylthioethyl or ethyl substituted by at least one halogen atom; R5 represents hydrogen, C1-4 alkyl, C1-4 hydroxyalkyl or C1-4 alkyl substituted by at least one halogen atom; and X represents carbon or nitrogen.

L'invention concerne un composé représenté par la formule générale (I),ayant une activité antivirale. Dans cette formule, R?1¿ représente un hydrogène, un alkyle en C¿1-6? ou un aralkyle en C¿7-10?; R?2¿ représente un alkyle en C¿1-6?, un aralkyle en C¿7-10? ou un phényle; R?3¿ et R?4¿ représentent chacun, de manière indépendante, un hydrogène, un alkyle en C¿1-6?, un acyloxyméthyle, un acylthioéthyle ou un éthyle substitué par au moins un atome d'halogène; R?5¿ représente un hydrogène, un alkyle en C¿1-4?, un hydroxyalkyle en C¿1-4? ou un alkyle en C¿1-4? substitué par au moins un atome d'halogène; et X représente un carbone ou un azote.

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