C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/395 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/65 (2006.01) A61K 31/675 (2006.01) A61P 31/04 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2605481
The present invention relates to phosphonated fluoroquinolones such as moxifloxacm, gatifloxacm and ciprofloxacin, antibacterial analogs thereof, and methods of using such compounds The disclosed compounds represent prodrugs of fluoroquinolones wherein a phosphonated group is tethered to a fluoroquinolone antibiotic via a cleavable linker These compounds are useful as antibiotics for prevention and/or treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis
La présente invention se rapporte à des fluoroquinolones phosphonées, à des analogues antibactériens de celles-ci, et à des procédés d'utilisation de tels composés. Lesdits composés sont utiles en tant qu'antibiotiques destinés à prévenir et/ou à traiter des infections osseuses et articulaires, en particulier l'ostéomyélite.
Delorme Daniel
Dietrich Evelyne
Houghton Tom
Kang Ting
Lafontaine Yanick
Gowling Lafleur Henderson Llp
Targanta Therapeutics Inc.
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