Phosphonated glycopeptide and lipoglycopeptide antibiotics...

Details Phosphonated glycopeptide and lipoglycopeptide antibiotics... Phosphonated glycopeptide and lipoglycopeptide antibiotics...

C - Chemistry, Metallurgy

07

K

C07K 9/00 (2006.01) A61K 31/663 (2006.01) A61K 38/08 (2006.01) A61K 38/14 (2006.01) A61P 19/08 (2006.01) A61P 31/04 (2006.01) C07F 9/38 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2673678

The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compounds are useful as antibiotics for the prevention or treatment of bone and joint infections, especially for the prevention and treatment of osteomyelitis.

La présente invention concerne des composés antimicrobiens qui présentent une affinité pour se lier aux os. Plus particulièrement, l'invention concerne des dérivés phosphonés d'antibiotiques à base de glycopeptides ou de lipopeptides. Ces composés sont utiles comme antibiotiques pour la prévention ou le traitement d'infections osseuses et articulaires, en particulier pour la prévention et le traitement de l'ostéomyélite.

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