C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6558 (2006.01) A61K 31/662 (2006.01) A61K 31/665 (2006.01) A61K 31/675 (2006.01) A61P 9/00 (2006.01) C07F 9/6571 (2006.01) C07F 9/6584 (2006.01)
Patent
CA 2706475
The invention relates to 2-phenyl-pyrimidine derivatives containing a phosphonic acid motif and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. (I).
L'invention concerne les dérivés de 2-phényl-pyrimidine contenant un motif d'acide phosphonique et leur utilisation comme antagonistes du récepteur P2Y12 dans le traitement et/ou la prévention de maladies vasculaires périphériques, viscérales, hépatiques et vasculaires rénales, cardiovasculaires et cérébrovasculaires ou de troubles associés à l'agrégation plaquettaire, y compris la thrombose chez les humains et les autres mammifères.
Caroff Eva
Hilpert Kurt
Hubler Francis
Meyer Emmanuel
Renneberg Dorte
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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