A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/662 (2006.01) A61P 3/10 (2006.01) C07F 9/40 (2006.01)
Patent
CA 2330111
Novel phosphonic diester derivatives represented by general formula (1) or pharmacologically acceptable salts thereof which are useful as drugs, wherein R1 represents amino, N-(lower alkyl)amino, N-(lower alkenyl)amino, etc.; R2 and R3 represent each hydrogen, lower alkyl, halogeno, lower alkoxy etc.; R4 represents hydrogen, lower alkyl or phenyl(lower alkyl); R5 and R6 represent each lower alkyl; X, Y and Z are all carbon atoms, or one of X, Y and Z is a nitrogen atom while other two are carbon atoms; and Q represents a single bond or alkylene.
L'invention concerne des dérivés de diester phosphonique représentés par la formule générale (1), ou leurs sels pharmaceutiquement acceptables. Ces produits sont utiles comme médicaments. Dans ladite formule générale, R<1> est amino, N-(alkyle inférieur)amino, N-(alcényle inférieur)amino, etc.; R<2> et R<3> sont chacun hydrogène, alkyle inférieur, halogéno, alcoxy inférieur, etc.; R<4> est hydrogène, alkyle inférieur ou phényle (alkyle inférieur); R<5> et R<6> sont chacun alkyle inférieur; X, Y et Z sont tous des atomes de carbones, ou bien l'un d'eux est un atome d'azote tandis que les deux autres sont des atomes de carbone; et Q est une liaison unique ou alkylène.
Inoue Yasuhide
Kawamura Kenichi
Miyata Kazuyoshi
Sakai Yasuhiro
Tsuda Yoshihiko
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Factory Inc.
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